PicoSure Pro: Complete Buyer's Guide
analytics Quick Specifications
Wavelengths
PicoSure Pro is Cynosure Lutronic's current-generation 755 nm Alexandrite picosecond workstation. The PicoSure family helped establish the U.S. picosecond-laser category after its first FDA clearance in November 2012, with Cynosure introducing the Pro generation in 2022. The base architecture centers on 755 nm; optional 532 nm and 1064 nm delivery systems broaden tattoo-color and skin-type coverage.
Unlike competitors that lean heavily on Nd:YAG (1064nm/532nm), the native 755nm Alexandrite wavelength offers a distinct absorption profile highly specific to melanin while sparing surrounding vasculature — a meaningful differentiator for blue and green tattoo inks and selected pigment targets.
Pulse Duration
PicoSure Pro operates at approximately 500–750 picoseconds (ps) at 755 nm; the optional 1064 nm mode is reported near 900 ps — buyers should verify the exact mode for their configuration. This delivers energy in a fraction of a second, relying on pressure (photoacoustic impact) rather than heat to treat pigment and stimulate skin revitalization safely across skin types.
Energy & Fluence
Delivering a pulse energy of 300 mJ (±20%) and a maximum fluence of 6.37 J/cm², the system provides sufficient photomechanical power for stubborn pigmentation while maintaining predictable clinical endpoints.
Spot Sizes
One Zoom handpiece offers a variable 2–6mm range for targeted work, alongside four fixed handpieces (5mm, 6mm, 8mm, 10mm) with adjustable fluence for rapid coverage of larger areas.
Fractional Technology
The Platinum Focus Lens Array: the platform's key clinical differentiator, offering more shots per cartridge than the standard Focus lens.
The Focus Lens Array uses microscopic diffractive lenses to redistribute 755nm energy into high- and low-intensity zones, creating Laser-Induced Optical Breakdown (LIOB) in the epidermis without ablating the stratum corneum.
This stimulates collagen and elastin production with minimal downtime, making it a tool for skin revitalization, acne scarring, and fine lines — labeled for Fitzpatrick skin types I–IV.
FDA-Cleared Indications
- 510(k) clearance held since 2012 for the PicoSure family
- 755 nm labeling covers pigmented lesions and tattoos — all Fitzpatrick skin types (I–VI), with the Flat Lens
- Platinum Focus is labeled for acne scars and wrinkles in Fitzpatrick skin types I–IV
- One of the few picosecond devices labeled to address melasma pigment, Nevus of Ota and Hori macules
- The optional 532 nm and 1064 nm systems carry their own wavelength-specific tattoo and pigment indications
Approximate Pricing
Manufacturer Direct
*Planning range only — replace with a current written quotation for the exact configuration.
Secondary Market
*Pre-owned pricing is not consistently public — confirm shot count, condition, included handpieces and Pro-generation status directly with the seller.
Principal Strengths
- check_circle Established market history — the PicoSure family has roughly 14 years of U.S. regulatory and commercial presence.
- check_circle Native 755 nm architecture — a meaningful differentiator for blue and green tattoo inks and selected pigment targets.
- check_circle Specific pigment labeling — current materials expressly address melasma pigment, Nevus of Ota and Hori macules.
- check_circle Fractional capability — Platinum Focus extends the platform beyond full-beam tattoo and pigment procedures.
- check_circle Brand and evidence maturity — substantial clinical literature, recognition and an active secondary market.
Limitations & Buyer Risks
- error Premium acquisition cost — a planning range of $225,000–$300,000 should be replaced by a current written quotation.
- error Optional wavelength economics — the base system does not automatically include 532 nm or 1064 nm delivery.
- error Configuration complexity — capabilities vary by generation, wavelength system, lens, handpiece, software and labeling.
- error Electrical requirements — the system generally requires 200–240 V service rather than a standard receptacle.
- error Opaque ownership costs — warranty length, service contracts and transfer or inspection fees are not consistently public.
Who Might Consider This Platform?
PicoSure Pro is best suited for an established dermatology, plastic-surgery or high-volume aesthetic practice that values premium brand recognition, mature clinical evidence, strong 755 nm pigment and blue/green tattoo performance, and fractional revitalization.
It is less suited to a budget-constrained startup or a buyer who requires 532 nm and 1064 nm as standard equipment rather than an add-on.
Ownership Considerations
Bottom Line
PicoSure Pro holds a defensible premium position because of its 755 nm Alexandrite architecture, long market history, clinical recognition and Platinum Focus fractional capability. Its most important purchasing limitation is configuration economics: comprehensive tattoo coverage may require separately priced 532 nm and 1064 nm systems. The platform is strongest when evidence, brand maturity and 755 nm performance outweigh price sensitivity.
Buyer note: Specifications, indications, pricing, warranty and service terms should be verified for the exact quoted configuration. This profile is a purchasing aid, not clinical, legal or regulatory advice.
Pico Laser Interactive Spotlight Table
Click any column header to sort from highest to lowest and lowest to highest
| PicoTech | 5 Standard: 1064, 532, 755, 585, 650nm | 2 Standard – Honeycomb 120px & 1064 DOE 49px | 350ps | 350ps | 800mj | 25.46 J/cm2 | 2 Years | $60,000 |
| PicoSure Pro | 1 Standard: 755nm (532, 1064nm optional) | 1 Standard Platinum Focus™ Lens Array | 900ps (500ps@755) | 450ps | 300mj | 9.55 J/cm2 | 1 Year | $200,000 |
| PicoWay | 2 Standard: 1064, 532nm (730, 785nm optional) | 0 Standard – Resolve Fractional optional | 343ps | 294ps | 400mj | 12.73 J/cm2 | 1 Year | $250,000 |
| Discovery Pico | 2 Standard: 1064, 532nm (694nm ruby on Plus) | 0 Standard – Optional Microbeam HC/DF | 450ps | 370ps | 800mj | 25.46 J/cm2 | 1 Year | $160,000 |
| PicoPlus | 2 Standard: 1064, 532nm (595, 660nm optional) | 0 Standard – Optional Dual Focused Dots | 450ps | 450ps | 800mj | 25.46 J/cm2 | 1 Year | $160,000 |
| PicoCare Majesty | 2 Standard: 1064, 532nm (595, 660nm optional) | 0 Standard – Optional MLA/DOE | 250ps | 180ps | 500mj | 15.92 J/cm2 | 1 Year | $125,000 |
| PicoLazer | 2 Standard: 1064, 532nm | 1 Standard – Fractional Handpiece | 450ps | 450ps | 500mj | 15.92 J/cm2 | 1 Year | $95,995 |
| PicoLO Premium | 2 Standard: 1064, 532nm | 1 Standard – Dia FX fractional | 450ps | 380ps | 500mj | 15.92 J/cm2 | 1 Year | $150,000 |
| PicoStar | 2 Standard: 1064, 532nm | 0 Standard – Optional MicroSpot PICO | 300ps | 300ps | 800mj | 25.46 J/cm2 | 1 Year | $180,000 |
| StarWalker PICO Pro | 2 Standard: 1064, 532nm (585, 650nm optional) | 1 Standard – FracTAT® & FracRevive | 300ps | 300ps | 800mj | 25.46 J/cm2 | 1 Year | $180,000 |
| PicoClear | 4 Standard: 1064, 532, 585, 650nm | 1 Standard – PicoLift 7×7 fractional | 350ps | 300ps | 450mj | 14.32 J/cm2 | 1 Year | $120,000 |
| PICOHI 300 | 2 Standard: 1064, 532nm | 0 Standard – Optional VMLA, ZMLA, DOE | 300ps | 275ps | 500mj | 15.92 J/cm2 | 1 Year | $95,000 |
| PicoFusion HS-298 | 2 Standard: 1064, 532nm | 0 Standard – Optional MLA/DOE | 350ps | 300ps | 500mj | 15.92 J/cm2 | 2 Years | $129,000 |
| Picofy | 2 Standard: 1064, 532nm | 0 Standard – Optional Array MLA 110 & Peak MLA 60 | 300ps | 300ps | 500mj | 15.92 J/cm2 | 1 Year | $160,000 |
| enlighten III | 3 Standard: 1064, 532, 670nm | 0 Standard – Optional MLA Handpiece | 750ps | 750ps | 600mj | 19.10 J/cm2 | 1 Year | $180,000 |
| PiQo4 | 4 Standard: 1064, 532, 585, 650nm | 0 Standard | 500ps | 500ps | 650mj | 20.69 J/cm2 | 1 Year | $180,000 |